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Most preclinical studies utilize supraphysiologic doses, alternate routes of administration and short follow-up windows that do not mimic human reproductive timelines

However, the review rated the overall evidence quality as very low due to small sample sizes, short follow-up periods, high risk of bias, and predominantly manufacturer-funded studies

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PCAB-accredited compounding pharmacies are held to rigorous standards for potency testing, ingredient sourcing, and compounding consistency

Whilst not reaching the maintenance dose of Wegovy could be considered as an off license use of the medication, under the appropriate qualified supervision a medical judgement can be made on the appropriateness of continuation of treatment on a lower dose