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"There are diseases of the stomach, including gastric atrophy, that contribute to B12 deficiency," explains Dr

The alteration in composition and function of gut microbiome in patients with type 2 diabetes

the inventors also surprisingly found inhibitory activity with certain embodiments of the invention where R 1 is methyl with dual positional substitutions (see e.g., compounds 2j, 2m, 2k, and 2l, Table 2)