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Abbreviations AKT: Protein kinase B CMA: Chaperone-mediated autophagy DEPTOR: DEP domain containing mTOR-interacting protein DNA-PK: DNA-dependent protein kinase ER: Endoplasmic reticulum FOXO1/3a: Forkhead box O1/3a GFAP: Glial fibrillary acidic protein GSK3: Glycogen synthase kinase-3 Hsc70: Heat shock cognate 71 kDa protein ILK: Integrin-linked kinase LAMP2A: Lysosome-associated membrane protein type 2A MAM: Mitochondria-associated endoplasmic reticulum membrane mLST8: Mammalian lethal with Sec13 protein 8 mPTP: Mitochondrial permeability transition pore mSin1: Mammalian stress-activated protein kinase-interacting protein 1 mTOR: Mechanistic target of rapamycin mTORC1: Mechanistic target of rapamycin complexes 1 mTORC2: Mechanistic target of rapamycin complexes 2 PDK1: Phosphoinositide-dependent protein kinase 1 PHLPP1: Leucine-rich repeat protein phosphatase 1 PI3K: Phosphatidylinositol-3-kinase-related kinase Rictor: Rapamycin-insensitive companion of mTOR SGK1: Serum- and glucocorticoid-inducible kinase 1 TSC2: Tuberous sclerosis complex UPS: Ubiquitin proteasome system VDAC1: Voltage-dependent anion channel 1 References Groll M, Huber R

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The cell counting kit-8 (CCK8) assay was used to examine cell viability

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