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It was discovered that tesofensines ability to reduce food intake was primarily mediated through the stimulation of alpha-1 adrenoceptors and dopamine D1 receptors

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Ablation of Sox2 from SOX2 + cells or elimination of SOX2 + cells via DTA severely depleted SOX2 + and AQP5 + cells but not KRT8 + ductal cells indicating Sox2 and SOX2 + cells were necessary for maintaining functional acini (Fig 2AD