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Description

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

Thus with the help of a glutathione assay, GSH/GSSG ratio is determined and the level of oxidative stress can be measured

The therapeutic window for inhibiting GGT as a cancer therapy is potentially large, as sustained inhibition of GGT activity did not induce any overt toxicities

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When administered under medical supervision with safety screening, common side effects are mild, including temporary tenderness at the IV site and occasional mild nausea