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Verdict at a Glance CagriSema and tirzepatide achieve remarkably similar weight loss (20.4% vs 20.9%) through fundamentally different dual mechanisms -- amylin/GLP-1 versus GIP/GLP-1

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In addition, c-Met/HGF axis modulates and interferes with other pathways such as pentose phosphate pathway, amino acid metabolism, and TCA cycle leading to its aggressive phenotypes