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To minimize gastrointestinal side effects, clinicians start semaglutide at a low dose and titrate slowly, maintaining stable levothyroxine dosing until weight stabilizes

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Patients Weighing Less than 50 kg:Total clearance of fondaparinux sodium is decreased by approximately 30% in patients weighing less than 50 kg [see Dosage and Administration (2.4) and Contraindications (4)]

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