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Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Moreover, this metabolic shift from glycolysis to FAO in senescent ECs is closely associated with increased secretion of proinflammatory factors characteristic of the senescence-associated secretory phenotype (SASP), which exacerbates chronic vascular inflammation (often referred to as inflammaging) and contributes to vascular diseases such as atherosclerosis and hypertension [105]

102.Viswanathan VS et al

Non-energetic metabolism of lipids in the kidneys produces several metabolites that play significant roles in the regulation of blood pressure through their effects on renal hemodynamics and tubular transport

353 Thus, increasing GLUT expression levels may help mitigate the progression of PD