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A sufficiently high concentration of clofazimine, as multiples of its 90% effective concentration (EC 90 ) in different cell lines (EC 90 of 0.81 to 2.35 M), is known to accumulate in plasma and lung tissue after several doses 18

Model and physiological RS 2 and RSSR substrates are, for example, bis(2-hydroxyethyl)disulfide (HEDS) 1,3,12,14,30 , l-cystine 1,3 , redox-sensitive yellow or green fluorescent protein 2 (rxYFP or roGFP2) 14,15,31,32,33,34,35 , insulin 36,37 , collapsin response mediator protein 2 38,39 , the transcription factor OxyR 40 , 3-phosphoadenosine 5-phosphosulfate reductase (PR) 41,42 , methionine sulfoxide reductase (MSR) 34,43,44 , and ribonucleotide reductase (RNR) 2,34,45,46,47

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5) Pre-existing skin conditions Depending on hormonal influence and shifts in the immune system, pre-excising skin conditions such as eczema, psoriasis, and rosacea may worsen or actually improve with pregnancy