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CHAC2 expression is also closely linked to several genetic mutations prevalent in breast cancer, most commonly TP53, as well as CDH1, BIRC6, DYNC2H1 and UTRN ( Thus, like CHAC1, CHAC2 represents an intriguing and complex target for further cancer research

AG-221 was found to suppress 2-hydroxyglutarate (2-HG) levels in hematopoietic cells expressing mutant IDH2 R140Q , and in murine models of IDH2-mutant leukemia

A 2014 study evaluated these functions by comparing a group of healthy patients that was supplemented with 4 months of either zeaxanthin, lutein, and mixed omega-3 fatty acids, or solely zeaxanthin, against a placebo group

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A reduced transferrin saturation is independently associated with excess morbidity and mortality in older adults with heart failure and incident anemia