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Description

The synergistic and toxicitylowering effects of AC as an adjuvant to oxaliplatin in HCC therapy was also recently highlighted

Sakuragi, M

Product glucuronides are exported from hepatocytes by MRP2 (canalicular, into bile) and MRP3/MRP4 (basolateral, into blood for renal excretion)

Additionally, it is subject to limited absorption by the small intestine and fast elimination by the gallbladder and its oral bioavailability is minimal

Indicatively, an initial cycle of 3-4 weekly infusions is recommended for NAD+ and a cycle of 4-6 total infusions for glutathione, followed by a maintenance phase