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Pfleger J, Gross P, Johnson J, Carter RL, Gao E, Tilley DG, et al

Pathophysiological changes Acute altitude illness Since AMS is a self-limiting and nonlethal disease, its pathophysiology is relatively unexplored

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For example, MMP-9, produced by both AECs and Thy-1-negative fibroblasts, not only activates TGF- to sustain a profibrotic cycle but also enhances fibroblast migration and collagen deposition (Kobayashi et al., 2014), thereby contributing to abnormal alveolar bronchiolization