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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

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Meta-analysis of real-time fMRI neurofeedback studies using individual participant data: How is brain regulation mediated

Additionally, a study reported a significant increase in the frequency of LDNs in the circulating blood of patients with COVID-19, which correlated with the severity of the disease, particularly in severe or critical patients

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