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When p53 is inactivated, the accumulation of DNA damage leads to sustained senescence induction through p16 expression 29

In particular, GH opposes the actions of insulin: it increases glucose production through gluconeogenesis and glycogenolysis in the liver and kidney, suppresses glucose uptake in adipose tissues, and is lipolytic

Furthermore, we observed enrichment of the relaxin signaling pathway at early iHLO phase, indicating an environment conducive to early liver epithelial cell differentiation