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Although often perceived as a means of enhancing muscle mass and physical performance, this practice represents a growing public-health concern due to its wide-ranging endocrine, reproductive, and multisystem adverse effects

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This raised the level of oxidative stress that can further lead to renal complications (Liakopoulos et al., 2017)

To obtain orthogonal proof that our inhibitors bind to the NADP + -TGR(H) forms, we evaluated their effect on thermal stability of TGR using the thermal shift assay (TSA or differential scanning fluorometry)

Given the differing etiology of HFpEF, it is speculated that there is a greater degree of heterogeneity in inflammation associated with this type of HF