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These seemingly paradoxical effects may be one explanation for why patients with G6PD-d display increased susceptibility to infection indicative of an impaired immune response, while also displaying increased autoimmunity and inflammation indicative of an overactive immune system 13

Phase II Conjugation Enzymes8 Methyltransferase Detoxification Enzymes and Methylation Capacity A cells methylation capacity is defined as the ratio of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH)

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Bromberg A, Lerer E, Udawela M, Scarr E, Dean B, Belmaker RH, Ebstein R, Agam G (2012) Nicotinamide- N -methyltransferase (NNMT) in schizophrenia: genetic association and decreased frontal cortex mRNA levels

45, 46, 47 Endotoxins are highly toxic lipopolysaccharides (LPS) of the outer cell wall of Gram-negative bacteria