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Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current

10.1007/s40009-019-00799-w 60 PetkauA.ChelackW

This intrinsic plasticity underlies not only the rapid emergence of resistance, the persistence of tumor heterogeneity, and the adaptive evolution of cancer

IL-6, IL-8, and IL10 levels were measured in culture supernatant using Quantikine Human ELISA kits (R&D Systems)

Collectively, targeted inhibition of SUV39H1 demonstrates efficacy in attenuating post-injury neointima formation, positioning it as a novel therapeutic candidate for proliferative vasculopathy including in-stent restenosis (31)