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Macrophages in lung fibrosis

2021 Jan 6;13(1):e12539

6 There have been studies revealing that metabolites and metabolic enzymes serve as key factors that influence signaling networks by providing molecules that act as energy sources, substrates, co-factors, and signals themselves

[471] Compared to naloxone which has a half-life of approximately 2 hours and also rapidly reverses the effects of an opioid overdose, nalmefene has a half-life of 11 hours which means that it remains in the body much longer than other overdose reversal drugs