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Peer review Peer review information Nature Chemical Biology thanks James Nathan, Ashley Solmonson and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Neurological and neuropsychological assessments were performed by the same team and using the same protocol as in Stanford-ADRC

Glucose deprivation and its influence on the NADH/FADH2 gradient modulate supercomplexes, enhance mitochondrial respiration, improve all parts of the respiratory chain, and increase cristae density (Cogliati et al., 2021) Studies suggest that fasting supports the balance between the fusion and fission states and homeostasis in the mitochondrial network in multiple cells and organs (Liesa and Shirihai, 2013