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A final alternative to alleviate FcRn-controlled pathological mechanisms could be to alter FcRn in itself, as may be intended with a gene therapy being developed in a collaboration between Beam and Apellis for a one-time dose of gene-editing molecules targeting FcRn [436, 437]

These polymorphisms are unrelated to cobalamin metabolism and the elevated MMA levels do not, by themselves, indicate a B12 deficiency (Molloy, 2016)

The MHRA Drug Safety Update (2022) highlights this association and recommends considering periodic monitoring in at-risk patients

Understanding Its Use in Multi-Dose Vials Multi-dose vials are common in peptide and hormone reconstitution

Sarkar T, Dhar S, Sa G