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Bhowmick, N

a, Conference abstract

The analysis of Nrf2 response in AD brain demonstrated decreased Nrf2 nuclear localization as well as its decreased expression and phosphorylation on Ser40, thus supporting the overall reduced antioxidant activity (82)

However, with the advent of chlorpromazine in the 1950s and the subsequent development of new pharmacological agents, the use of this therapy has declined considerably (118)