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So low homocysteine may be a sign of oxidative stress.Formation of more cysteine from homocysteine would then deplete the homocysteine pool to support the formation of GSH to combat the free radicals

Int J Mol Sci (2018) 19(8):2396

Reinicke et al

Use of antiemetic drugs during pregnancy in Sweden

The authors of these studies found Arg35 was highly conserved and was found in 68% of Alpha, Mu, Pi and Sigma GST sequences also containing a catalytic Tyr residue using a query motif [Y] 7X [E, Q, H] 2X [R] 1011X [E, D] 12X [R, K]