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There is some evidence that hormone therapy may help some women with osteoarthritis

For recovery enhancement, performance optimisation, or longevity goals in healthy people, until a randomised, placebo-controlled trial in a defined population with an objective primary endpoint and pharmacovigilance over a clinically meaningful duration produces data we do not currently have, we just don't have good evidence of benefit, let alone safety

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Yes, please

4 Dealing with back pain for five minutes, never mind five years, makes it clear that the issue is a serious quality-of-life issue