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While BVZ is well tolerated, suppression of VEGF activity often results in some common toxicities, such as hypertension, gastrointestinal perforation, thromboembolic events, cerebral haemorrhage, problems with wound healing, and proteinuria etc

For instance, Muthan et al

The conversion of vitamin B 6 to its active coenzyme form in tissues, pyridoxal 5'-phosphate (PLP), requires the FMN-dependent enzyme, pyridoxine 5'-phosphate oxidase (PPO) (7)

Synaptic and cellular changes induced by the schizophrenia susceptibility gene G72 are rescued by N-acetylcysteine treatment