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@sigtor2019 (May 25, 2022)

The deadline for written comments is July 22, 2026 the day before the meeting convenes

Since the publication of the CY 2022 PFS final rule, we have given additional consideration to the comments discussed above

Identification of risk factors for bleeding and certain genetic variation in CYP2CP and VKORC1 in a patient may increase the need for more frequent INR monitoring and the use of lower warfarin doses (see CLINICAL PHARMACOLOGY: Metabolism and DOSAGE AND ADMINISTRATION)