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This alternative pathway, relying on CD44-mediated endocytosis, becomes the dominant iron uptake mechanism compared to the traditional TfR1-dependent route

Langston JW, Forno LS, Rebert CS, Irwin I

FIGURE 3 8 Discussion Parkinsons disease is characterized by neuroinflammation caused by microglia, which exhibit both neurotoxic and neuroprotective effects depending on their activation state in the brains of individuals with PD

Combination of Immune Checkpoint Inhibitor Therapy and Radiotherapy ICIs treatment targeting programmed cell death receptor 1 (PD-1) and programmed cell death ligand 1 (PD-L1) have shown solid clinical efficacy (70, 71)