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The benefits appear to be strongest when treatment starts early

doi: 10.1038/laban.254 28 TownsendDMTewKD

Melatonin reduces excitotoxic blood-brain barrier breakdown in neonatal rats

The interconversion between polyamines depends on the function of key enzymes such as spermine oxidase (SMOX), acetylpolyamine oxidase (PAOX), spermidine/spermine-N1-acetyltransferase (SSAT), SRM, and SMS [279]