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Cinti S, Enzi G, Cigolini M, Bosello O

Epub 2008/08/30

J Neurol 248:469477 Schousboe A (1981) Transport and metabolism of glutamate and GABA in neurons are glial cells

In the PNS, thiamine deficiency can result in polyneuritis and paralysis, as seen in dry beriberi, which affects the sensory system, causing pain, altered temperature sensitivity, numbness, reduced tendon reflexes, and leg atrophy ( Pan et al, in a in vivo study performed with transgenic mice, have shown that chronic treatment with benfotiamine, a thiamine derivate with better bioavailability, enhanced the spatial memory and reduced both amyloid plaque numbers and phosphorylated tau levels, suggesting that this thiamine derivative may be useful in clinical Alzheimers disease treatment, although others thiamine derivatives do not showed the same results ( Table 2 )

Noradrenaline causes retraction of microglial cellular extensions in both resting and activated microglia