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AnkB-deficient animals have sinus bradycardia, a prolonged QT interval, and other myocardial electrical phenotype changes, promoting myocardial mechanical remodelling as well as premature death, which is related to the low expression of -catenin in the intercalated disc and high expression in the cytoplasm caused by the loss of AnkB

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Together, these findings position DSIP as a multifunctional neuropeptide used in experimental models to investigate the integration of signaling pathways involved in sleep regulation, stress response, neuroprotection, and endocrine coordination