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Evidence-based medicine: a movement in crisis

In addition, sulforaphane is an HDAC inhibitor used to treat colorectal cancer that can inhibit tumor progression by targeting HDAC1 and HDAC2 [353, 354]

10.3389/fncel.2014.00058 12 BassellG

Recently, riluzole has initiated a phase II, placebo-controlled, randomized, double-blind, parallel, multicenter, prevention trial with adult stage II/III colorectal cancer patients treated with a simplified FOLFOX4 regimen in the adjuvant setting (NCT03722680)