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Overall, although we have not significantly improved the hit activity in cells, the interesting results obtained for the analogues have confirmed that the scaffold we have identified confers NS3-NS5 inhibitory activity and can be used as a starting point for further structural optimization studies

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

AOPs are understood to endorse the degradation of organic compounds through the mechanism of hydroxyl radicals (OH) formation in the primary stages

Among individual proteins showing significant changes, GAPDH displayed markedly increased active site acetylation (K143 and C150) in cold-exposed BAT (Fig