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doi: 10.1371/journal.pntd.0008505 169 MoreelsT

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Int Arch Allergy Immunol 185(5):425435

While Fmr1 /y mice older than 6 months displayed significant defects in the expression of cortical LTP, the mice never displayed any impairment in hippocampal LTP

Indications Citalopram is FDA-approved to treat the following disorders (11): Depression in adults Citalopram is prescribed off-label to treat: Obsessive-compulsive disorder (OCD) Panic disorder Generalized anxiety disorder (GAD) Social anxiety disorder (SAD) Premenstrual dysmorphic disorder (PMDD) Binge eating disorder Posttraumatic stress disorder (PTSD) Premature ejaculation Poststroke depression Mechanisms of Action and Pharmacokinetics Citalopram escalates the brain-derived neurotrophic factor (BDNF) in the hippocampus and prefrontal cortex, which can be decreased in patients with depression (18)