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12, 13 The oncogenic transcription factor MYC mediates the transcription of almost all the genes involved in glycolysis and glutaminolysis, 6, 14 and it promotes shuttling of glycolytic intermediates to pentose phosphate pathway to generate large quantities of reduced nicotinamide adenine dinucleotide phosphate (NADPH) and promote macromolecule biosynthesis via the induction of pyruvate kinase isozymes M2 (PKM2)

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Q.ZhouL.StybloM.WaltonF.JingY.WeinbergR.et al (2003)