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Using the safety and feasibility data from these first-inhuman trials demonstrating that intermittent D+Q was well tolerated in 50 subjects (NCT 02874989 and NCT 02848131), combined with the efficacy data in mouse models, we initiated a Phase I study of senolytic therapy in older adults with early-stage symptomatic AD, SToMP-AD (Senolytic Therapy to Modulate the Progression of Alzheimers Disease, NCT04063124) (107)

[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Zhou, Y., Wang, S., Li, Y., Yu, S

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J Biol Chem 250(4):14221426 Robertson G, Leclercq I, Farrell GC (2001) Nonalcoholic steatosis and steatohepatitis

7C), demonstrating a DNA hydroxymethylation dependent regulatory effect of DMF