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The toxicity of free radicals contributes to the damage of cellular macromolecules (such as DNA, proteins and lipids), inflammation, tissue damage and subsequent cellular apoptosis (Reference Ames, Shigenaga and Hagen14)

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PRDM16 is a transcriptional regulator that induces the expressions of UCP1, PGC1, and type 2 deiodinase and enhances the uncoupling of respiration, thus maintaining brown fat characteristics, including thermogenic function [42,43]

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