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For example, the VP1 H248P mutation alters the surface charge of the VP1 HI loop, inducing conformational changes in the BC and HI loops (Supplementary Fig

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DOI:10.7883/yoken.66.480 105

In the design of SMN-C2, a longer linker was incorporated to enhance the interaction of SMN-C2-VQ with the hairpin loop structure and facilitate access to the distant U base

has served as a consultant for AbbVie, Aclaris Therapeutics, BiologicsMD, EMD Serono, Genzyme/Sanofi, Janssen, Pfizer, Rheos Medicines, Sun Pharma, TeVido BioDevices, The Expert Institute, Third Rock Ventures and Villaris Therapeutics, has served as an investigator for Aclaris Therapeutics, Celgene, Dermira, EMD Serono, Genzyme/Sanofi, Incyte Corporation, LEO Pharma, Pfizer, Rheos Medicines, Stiefel/GlaxoSmithKline, Sun Pharma, TeVido BioDevices and Villaris Therapeutics, holds equity in Aldena Therapeutics, NIRA Biosciences, Rheos Medicines, TeVido BioDevices and Villaris Therapeutics, is a scientific founder of Aldena Therapeutics, NIRA Biosciences and Villaris Therapeutics, and has patents pending for IL-15 blockade for the treatment of vitiligo, JAK inhibition with light therapy for vitiligo, and anti-human CXCR3 antibodies for treatment of vitiligo