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Malaguarnera M, Gargante MP, Cristaldi E, et al

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The expression of PGC1 and OXPHOS activities are increased in the long-living Ames dwarf mice (lack of GH, prolactin, and thyroid-stimulating hormone), demonstrating a negative effect of GH on mitochondrial biogenesis (Westbrook et al., 2009

Hydroxyl radicals directly target the different components of DNA such as deoxyribose sugar backbone, pyrimidine and purine bases, and result from single and double-stranded breaks in the DNA (Nita and Grzybowski, 2016)