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As type I interferons, known to be upregulated in SLE, transduce their signal through JAK, the JAK1 inhibitor GSK2586184 was used in a small trial to block the expression of interferon-related genes in SLE

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Abbasi GH, Akhtar J, Anwar-ul-Haq M, Ali S, Chen Z, Malik W

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Han C.H., Khwaounjoo P., Kilfoyle D.H., Hill A., McKeage M.J