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In the realm of skin disease treatment, the regulatory role of FSP1 could emerge as a potential target for addressing inflammatory skin conditions such as psoriasis and venous ulcers ( 2.9 AMPK AMPK plays a pivotal role in regulating ferroptosis as the primary sensor of cellular metabolic status and energy levels ( In-depth research has revealed that the activation of AMPK is regulated by its upstream kinase liver kinase B1 (LKB1), a significant tumor suppressor, particularly in malignant tumors such as lung cancer, where mutations in LKB1 are common ( When cells encounter ferroptosis-inducing factors, the activation of AMPK not only inhibits the activity of its downstream acetyl-CoA carboxylase 1 (ACC1) but also reduces the synthesis of fatty acids ( During the process of skin ferroptosis, the role of AMPK is particularly important