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There is a substantial increase in the total quantity of bacteria and notable changes in the composition of the gastrointestinal microbiota during pregnancy, especially in the latter stages

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This result strongly suggests that hGSTA4-4 and hGST5.8 are specifically adapted by human cells for the purpose of detoxifying 4-HNE to abrogate the downstream effects which such a buildup would cause

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Their destructive effects may contribute to the diseases initiation and propagation, as they damage the gut lining and activate inflammatory signaling pathways, further exacerbating the inflammation