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10.1016/s0022-2836(05)80154-8 8 BjrnestedtR.TardioliS.MannervikB

The findings suggest that the mechanisms involved in TMPs protective effects against AKI primarily revolve around the mitigation of OS injury, suppression of inflammation, prevention of apoptosis in intrinsic renal cells, and regulation of autophagy

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Thus, SSG does not simply suppress or promote apoptosis, but instead functions as a context-dependent redox rheostat that determines the threshold and direction of apoptotic signaling