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Description

Lindenmeyer points out

Ann Thorac Surg 96(4):1138-45, 2013

indicates downregulation (decrease)

Lu HC, Mackie K (2021) Review of the endocannabinoid system

However, when ROS and RNS levels become dysregulated, they can cause oxidative damage to lipids, proteins, and DNA, triggering inflammation, impairing synaptic function, and ultimately contributing to neuronal degeneration [368]