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2 Iliopoulos DC, Kritharis EP, Boussias S, et al

Metformin was selected as first-line treatment because of its record of safety and efficacy, as well as its low cost (Gold Standard 2015c)

Once within the mitochondria, PGAM5 dephosphorylates AIFM1 at Ser116, ultimately resulting in the induction of oxeiptosis in HeLa cervical cancer cells [74]