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It would be of importance to establish the association between zinc status and various CVDs

and bioorthogonal conjugation of immunomodulators to the EcN surface, where dissolution of an enteric coating in the intestine exposes the conjugates to drive macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2, complementing the probiotic's intrinsic effects (Peng et al., 2024)

Subsequent meta-analyses with larger sample sizes also confirmed this association (OR = 1.10, 95% CI = 1.061.14, P = 3.2 10 6 ) ( DAB2IP rs7025486[A] and early-onset CAD ( DAB2IP rs7025486[A] and CAD was not found