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10.1016/j.bbrc.2016.08.151 Biochem

The hypothesis suggests that the reduced concentration of linoleic acid in sebum induces a state of fatty acid deficiency in the cells of the follicular epithelium, resulting in abnormal differentiation and subsequent hyperkeratosis [188]

comprising successive sets of progeny molecules Previous Directed Evolution Methods Are Suboptimal: Mutagenesis has been attempted in the past on many occasions, but by methods that are inadequate for the purpose of this invention