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Description

The increase in glucose consumption by cancer cells was first described by Warburg [2]

In humans this oxidation repair enzyme is also known to participate in many cellular functions, including redox signaling and regulation of glucose metabolism

This in turn elevates HIF-1 levels, which act to enhance the expression of glycolytic enzymes and sustain a balance between Treg and pro-inflammatory Th17 cells by facilitating RORt-mediated transcriptional activation (8, 17)