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Broken Connections May Myalgic Encephalomyelitis/Chronic Fatigue Syndrome be a Case of Connectivity Hub Failure

Prade, L., Huber, R., Manoharan, T.H., Fahl, W.E., Reuter, W

In a multi-ethnic meta-analysis study (30,000 PTSD cases and 170,000 controls), non-coding RNAs such as Long Intergenic Non-Protein Coding RNA 2335 (LINC02335), microRNA 5007 (MIR5007), transcribed ultra-conserved region 338 (TUC338), (Long Intergenic Non-Protein Coding RNA 2571) (LINC02571), Long Intergenic Non-Protein Coding RNA 458 (LINC00458), microRNA 1297 (MIR1297) and Long Intergenic Non-Protein Coding RNA 558 (LINC00558) and PARK2 gene are involved in dopamine regulation, is associated with PTSD [20]

Its pleiotropic pharmacological properties particularly anti-inflammatory, antioxidant, and hormonal regulatory effects render it beneficial in the management of various gynecological disorders, including PCOS, PMS, dysmenorrhea, and gynecologic malignancies