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Author Contributions Conceptualization, M.M

It provides more predictive outcomes for human responses compared to traditional animal testing methods and accelerates development timelines

They are not for human consumption, medical use, veterinary use, or household use

Such heterogeneity implies that a study may claim an increase in a particular genus of bacteria in COVID-19 patients, whereas a different study in a different location may also not detect the growth or even may reverse the trend of that same genus, merely due to differences in the population structures and conditions underlying such studies [64]

This raises the notion that perhaps within konzo-prone regions of sub-Saharan Africa there may be genetic variants of GPx3, or genes related to associated pathways that circulate which could alter gene expression and subsequently cause a reduction of protein abundances in these populations