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Some researchers claim that deficiencies, especially in vitamin D, magnesium, zinc, and B vitamins, directly hinder insulin receptor signaling and ovarian hormone production, contributing to PCOS development

This downregulation subsequently inhibits NLRP3 inflammasome activation, leading to upregulation of GPX4/SLC7A11 or downregulation of ACSL4/ALOX15, and ultimately suppressing both ferroptosis and neuroinflammation

Antenatal diagnosis Antenatal diagnosis is possible and can be made by: Mutation analysis of chorionic villi (the method of choice if the mutation in the family is known)

doi: 10.1016/S0014-5793(00)01731-2 64

provided evidence that the interplay between the signals of mechanistic target of rapamycin kinase (mTOR) and GPX4 modulates autophagydependent ferroptosis in human pancreatic cancer cells, and the downregulated expression of GPX4 enhances the anti-cancer activity of rapamycin in vitro or in vivo by promoting ferroptosis and suppressing autophagy [38]