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Primary Handling Editor: Sonia Muliyil, in collaboration with the Nature Medicine team

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Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP Jr (2012) Association of biochemical B deficiency with metformin therapy and vitamin B supplements: the National Health and Nutrition Examination Survey, 19992006

A randomized, double-blind, placebo-controlled trial in 191 older adults (75 years) with moderate vitamin B 12 deficiency (serum cobalamin concentrations of 107-210 pmol/L) without anemia provided participants with 1 mg/day of cyanocobalamin for one year (94)